Piperidinyl and piperazinyl derivatives

Compounds of the formula: in which R1 is alkylsulfonamido of 1 to 6 carbon atoms, arylsulfonamido of 6 to 10 carbon atoms, -NO2,-CN, 1-imidazolyl or 1,2,4-triazol-1-yl; Y is -CH2-, -O-, -S-, or -SO2-; X is -CH= or -N=; R2 is hydrogen when n is 0, otherwise it is hydrogen or -OH; n is one of the inte...

Full description

Saved in:
Bibliographic Details
Main Authors BAGLI; JEHAN F, ELLINGBOE; JOHN W, BUTERA; JOHN A
Format Patent
LanguageEnglish
Published 13.04.1993
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:Compounds of the formula: in which R1 is alkylsulfonamido of 1 to 6 carbon atoms, arylsulfonamido of 6 to 10 carbon atoms, -NO2,-CN, 1-imidazolyl or 1,2,4-triazol-1-yl; Y is -CH2-, -O-, -S-, or -SO2-; X is -CH= or -N=; R2 is hydrogen when n is 0, otherwise it is hydrogen or -OH; n is one of the integers 0, 1, 2, 3, 4, 5 or 6; A is where R3 is alkylsulfonamido of 1 to 6 carbons atoms, arylsulfonamido of 6 to 10 carbon atoms, -NO2, -CN, 1-imidazolyl or 1,2,4-triazol-1-yl; or where R4 is hydrogen or alkyl of 1 to 6 carbon atoms; with the provisos that; a) X is -CH= when Y is -O- or -S- and when Y is and R2 is -OH; b) X is -N= when A is c) A is when Y is -S- or -SO2- and X is -CH=, and their pharmaceutically acceptable salts are Class III antiarrhythmic agents.
Bibliography:Application Number: US19920841922