INTERMEDIATES FOR PRODUCING ANTIPICORNAVIRAL PYRIDAZINAMINES

Piperidinyl, pyrrolidinyl, azepinyl and piperazinyl pyridazines of formula (I) wherein one or two carbon atoms of the moiety may be substituted with C1-4alkyl, C1-4alkyloxy or two carbon atoms of the CH2 groups of said moiety may be bridged with a C2-4alkanediyl radical; X represents CH or N; R1 rep...

Full description

Saved in:
Bibliographic Details
Main Authors STOKBROEKX; RAYMOND A, GRAUWELS; GILBERT A. J, LUYCKX; MARCEL G. M, VAN DER EYCKEN; CYRIEL A. M
Format Patent
LanguageEnglish
Published 23.03.1993
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
Online AccessGet full text

Cover

More Information
Summary:Piperidinyl, pyrrolidinyl, azepinyl and piperazinyl pyridazines of formula (I) wherein one or two carbon atoms of the moiety may be substituted with C1-4alkyl, C1-4alkyloxy or two carbon atoms of the CH2 groups of said moiety may be bridged with a C2-4alkanediyl radical; X represents CH or N; R1 represents hydrogen, C1-4alkyl, halo, hydroxy, trifluoromethyl, cyano, C1-4alkyloxy, C1-4alkylthio, C1-4alkylsulfinyl, C1-4alkylsulfonyl, C1-4alkyloxycarbonyl, C1-4alkylcarbonyl or aryl; R2 and R3 each independently represent hydrogen or C1-4alkyl; Alk represents C1-4alkanediyl; R4 and R5 each independently represent hydrogen, C1-4alkyl or halo; and Het represents (a) (b) (c) (d) (e) (f) (g) (h) the addition salts and stereochemically isomeric forms thereof, said compounds having antipicornaviral activity. Pharmaceutical compositions containing these compounds as active ingredient, and a method of preparing said compounds and pharmaceutical compositions.
Bibliography:Application Number: US19910789563