Vaccine for immunizing fish against infectious pancreatic necrosis virus

A vaccine for simultaneously immunizing large numbers of fish against infection by Infection Pancreatic Necrosis Virus (IPNV) is disclosed. The vaccine comprises viral capsid polypeptides produced from a recombinant expression vector in a compatible bacterial host. The expression vector includes IPN...

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Bibliographic Details
Main Author LEONG; JO-ANN C
Format Patent
LanguageEnglish
Published 24.11.1992
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A vaccine for simultaneously immunizing large numbers of fish against infection by Infection Pancreatic Necrosis Virus (IPNV) is disclosed. The vaccine comprises viral capsid polypeptides produced from a recombinant expression vector in a compatible bacterial host. The expression vector includes IPNV cDNA sequences encoding at least a portion of a capsid protein of IPNV, the portion capable of inducing immunity in susceptible fish to subsequent IPNV infection. A vaccine containing both capsid proteins of IPNV is particularly effective. The vaccine is administered by preparing a crude lysate from bacterial cells having the vector and adding the lysate to the water containing young fish. For the first time, large numbers of fish can be immunized against IPNV infection without having to inject vaccine into each fish.
Bibliography:Application Number: US19890346623