Automated protein hydrolysis system

Protein analysis apparatus has porous sample supports enclosed in holes in a sample slide. Slides are delivered to hydrolysis and derivatizer stations by a rotating turret such that moveable heads at the stations form closed reaction chambers with the slides, sealing around the holes in the slides a...

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Bibliographic Details
Main Authors HUGHES; JAN K, DUPONT; DAVID R, RAYSBERG; YEFIM M, SHULSE; ERIC
Format Patent
LanguageEnglish
Published 21.04.1992
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:Protein analysis apparatus has porous sample supports enclosed in holes in a sample slide. Slides are delivered to hydrolysis and derivatizer stations by a rotating turret such that moveable heads at the stations form closed reaction chambers with the slides, sealing around the holes in the slides and enclosing the sample supports. Tubings connected to the heads deliver substances for reaction, derivatization and cleaning. Protein samples applied to sample supports at one position on the turret are delivered sequentially to hydrolysis and derivatizer stations, and operations are computer controlled. Derivatives are automatically delivered for chromatographic analysis, and supports are automatically cleaned with solvents and purge gas after derivatization and before return to a sample load position. Closed reaction chambers formed by the moveable heads can be heated and pressurized as required for processing.
Bibliography:Application Number: US19890321230