Chemical compounds

Compounds of the formula (1) : or pharmaceutically acceptable salts thereof as described, wherein is a pyridine, pyrazine or triazine ring; R is C1-6alkyl, C2-6alkenyl, C3-5cycloalkylC1-6alkyl, or C1-6alkyl substituted by 1 to 6 fluoro groups; R is C1-6alkylthio, C1-6alkylsulphonyl, C1-6alkoxy, hydr...

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Bibliographic Details
Main Authors FLYNN; SEAN T, COATES; WILLIAM J, RAWLINGS; DEREK A
Format Patent
LanguageEnglish
Published 10.09.1991
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Compounds of the formula (1) : or pharmaceutically acceptable salts thereof as described, wherein is a pyridine, pyrazine or triazine ring; R is C1-6alkyl, C2-6alkenyl, C3-5cycloalkylC1-6alkyl, or C1-6alkyl substituted by 1 to 6 fluoro groups; R is C1-6alkylthio, C1-6alkylsulphonyl, C1-6alkoxy, hydroxy, hydrogen, hydrazino, C1-6alkyl, phenyl, -NHCOR wherein R is hydrogen or C1-6alkyl, or -NR R , wherein R and R together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino, hexahydroazepino, morpholino or piperazino ring, or R and R are independently hydrogen, C3-5cycloalkyl or C1-6alkyl which is optionally substituted by -CF3, phenyl, -S(O)nC1-6alkyl wherein n is 0, 1 or 2, -OR , -CO2R or -NR R wherein R to R are independently hydrogen or C1-6alkyl, provided that the carbon atom adjacent to the nitrogen atom is not substituted by said -S(O)nC1-6alkyl, -OR or -NR R groups; and when is a pyrazine ring it may be further substituted by hydroxy when R is hydroxy. Their use as medicaments, pharmaceutical compositions comprising them and processes for their preparation are also described.
Bibliography:Application Number: US19890365469