Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof

There is provided a novel and efficient stereoselective total synthesis of epipodoplyllotoxin and related epipodophyllotoxin compounds of the general formula wherein R1 and R2 each are independently hydrogen or (lower)-alkoxy, or R1 and R2, taken together, is methylenedioxy; R4 and R6 each are indep...

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Bibliographic Details
Main Authors VYAS; DOLATRAI M, SKONEZNY; PAUL M
Format Patent
LanguageEnglish
Published 12.09.1989
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION ORPROCESSING OF GOODS
GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC
GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINSTCLIMATE CHANGE
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Summary:There is provided a novel and efficient stereoselective total synthesis of epipodoplyllotoxin and related epipodophyllotoxin compounds of the general formula wherein R1 and R2 each are independently hydrogen or (lower)-alkoxy, or R1 and R2, taken together, is methylenedioxy; R4 and R6 each are independently hydrogen or (lower)alkoxy; and R5 is hydrogen or a phenol-protecting group; or an acid addition salt thereof. The present invention also provides novel intermediates and processes for the preparation of said intermediates, which are then converted into known antineoplastic agents.
Bibliography:Application Number: US19880245108