Process for the production of nourseothricine and its adsorbate

• Main Authors: GRAEFE; UDO, MUELLER; PETER-JUERGER, FORBERG; WOLFGANG, HELLER; INGEBORG, BORMANN; ERNST-JOACHIM, BOCKER; HARALD, POHL; HANS D, JUNNE; WOLF, THRUM; HEINZ, SCHNEIDER; JOERG, LINDE; HELLMUT, FRICKE; HEINZ, PLONKA; GUNTER, HILLIGER; MATTHIAS, MENZEL; KLAUS-DIETER, GROSSE; HANS-HELMUT, MENNER; MICHAEL, BERGTER; FRIEDRICH
• Format: Patent
• Language: English
• Published: 29.08.1989
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPIRITS; VINEGAR; WINE

A process is disclosed for the fermentative production of the ergotropically effective antibiotic nourseothricin, with which, using different carbohydrate sources and suitable inorganic and organic nitrogen sources as well as different mineral salts, with or without addition of stock substances of the respiratory chain or the intracellular amino acid transport, and through influencing the phosphate substance exchange and avoidance of further limitations with regulated acidity conditions, high concentrations of this antibiotic are cultivated in the culture solution. The recovery of the active substance in the culture solution follows either by chromatographic techniques in the form of salts or through addition of a physiologically compatible adsorbent as mycelium-containing nourseothricin-adsorbate, which preferably can be added to the dosaging of mixed feed agents.