Process for preparing heterocyclic compounds

A compound of formula (I) (I) is prepared by cyclizing a compound of formula (IIa) or (IIb) or a mixture thereof (IIa) (IIb) wherein X is hydroxyl or halogen and R1 and R2 independently, represent hydroxy protecting groups) followed by removal of the protecting groups R1 and R2. The compound (I) is...

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Bibliographic Details
Main Authors BRODIE; ALASTAIR C, HAYMAN; DAVID F, PROCOPIOU; PANAYIOTIS A
Format Patent
LanguageEnglish
Published 06.06.1989
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
THEIR RELEVANT APPARATUS
TRANSPORTING
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Summary:A compound of formula (I) (I) is prepared by cyclizing a compound of formula (IIa) or (IIb) or a mixture thereof (IIa) (IIb) wherein X is hydroxyl or halogen and R1 and R2 independently, represent hydroxy protecting groups) followed by removal of the protecting groups R1 and R2. The compound (I) is of use as an intermediate in the stereoselective preparation of (+/-) trans-5-fluoro-2,3,3a,9a-tetrahydro-1H-[1,4]benzodioxino[2,3-c] pyrrole, which is a selective beta 2-adrenoreceptor antagonist and is thus of potential value, in particular, for the treatment or prevention of depression.
Bibliography:Application Number: US19860922255