Preparation of 3-amino-4-hydroxybenzoic acids

This invention is a process for the preparation of a 3-amino-4-hydroxybenzoic acid which comprises (a) contacting a p-halobenzoic acid with nitric acid in an acidic reaction medium under conditions such that a 3-nitro-4-halobenzoic acid is prepared; (b) contacting the 3-nitro-4-halobenzoic acid with...

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Bibliographic Details
Main Author LYSENKO; ZENON
Format Patent
LanguageEnglish
Published 30.05.1989
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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Summary:This invention is a process for the preparation of a 3-amino-4-hydroxybenzoic acid which comprises (a) contacting a p-halobenzoic acid with nitric acid in an acidic reaction medium under conditions such that a 3-nitro-4-halobenzoic acid is prepared; (b) contacting the 3-nitro-4-halobenzoic acid with an alkali metal hydroxide in a reaction medium under conditions such that the halo moiety is replaced with a hydroxide moiety, to prepare a 3-nitro-4-hydroxybenzoic acid, or salt thereof; and (c) reducing the 3-nitro-4-hydroxybenzoic acid under conditions such that a 4-hydroxy-3-aminobenzoic acid is prepared.
Bibliography:Application Number: US19860827996