Novel benzothiazinone derivatives, processes for their preparation, medicaments containing them and their use

Benzothiazinone derivatives I (I) with R1 and R4 being H, alkyl, alkoxy, Hal, CF3, NO2, OH, acetamido or amino, R2 being H, (cyclo)alk(en)yl, cycloalkylakyl, phenyl or phenylalkyl, A being (CH2)mO(CH2)n, (CH2)p-CH(OH)-CH2)q, (CH2)p-CH(OCH3)-(CH2)q, or (CH2)rOCH2-CO- and (CH2)s-CO-, R5 being NR(6)R(7...

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Bibliographic Details
Main Authors LERCH; ULRICH, HENNING; RAINER
Format Patent
LanguageEnglish
Published 16.05.1989
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Benzothiazinone derivatives I (I) with R1 and R4 being H, alkyl, alkoxy, Hal, CF3, NO2, OH, acetamido or amino, R2 being H, (cyclo)alk(en)yl, cycloalkylakyl, phenyl or phenylalkyl, A being (CH2)mO(CH2)n, (CH2)p-CH(OH)-CH2)q, (CH2)p-CH(OCH3)-(CH2)q, or (CH2)rOCH2-CO- and (CH2)s-CO-, R5 being NR(6)R(7) or certain cyclic amines, show a calcium-antagonistic action. They are obtained, inter alia, from II (II) by reaction with III IIIa IIIb IIIc IIId IIIe A and B are same or different and are lower alkylene having 1 to 6 carbon atoms; and n is 3 to 4.
Bibliography:Application Number: US19870042867