Tyr-Arg-vasopressin antagonists

Vasopressin antagonists which have a dipeptide tail composed of a neutral and basic amino acid unit demonstrate potent V1 and V2-antagonist activity. Two species of this invention, which are prepared by solid phase peptide synthesis, are [1-( beta -mercapto- beta , beta -cyclopentamethylene propioni...

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Bibliographic Details
Main Author ALI; FADIA E
Format Patent
LanguageEnglish
Published 23.08.1988
Edition4
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Vasopressin antagonists which have a dipeptide tail composed of a neutral and basic amino acid unit demonstrate potent V1 and V2-antagonist activity. Two species of this invention, which are prepared by solid phase peptide synthesis, are [1-( beta -mercapto- beta , beta -cyclopentamethylene propionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-7-tyrosine-8-arginine-9-desglyci ne]-vasopressin and [1-( beta -mercapto- beta , beta -cyclopentamethylenepropionic acid)-2-(O-ethyl)-D-tyrosine-4-valine-7-arginine-8-tyrosine-9-desglyci ne]-vasopressin.
Bibliography:Application Number: US19860937955