Calcium antagonist piperazine derivatives, and compositions therefor

PCT No. PCT/JP85/00445 Sec. 371 Date Apr. 10, 1986 Sec. 102(e) Date Apr. 10, 1986 PCT Filed Aug. 9, 1985 PCT Pub. No. WO86/01203 PCT Pub. Date Feb. 27, 1986.Compounds of the formula: wherein A means an alkylene; Y-Z means -CH=CH-, -CH2CH2-, or R1 and R2 are each a substituent; R3 is hydrogen atom, a...

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Main Authors UNO; HITOSHI, SATO; FUMINORI, KUROKAWA; MIKIO, HATANO; NAONOBU
Format Patent
LanguageEnglish
Published 07.06.1988
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:PCT No. PCT/JP85/00445 Sec. 371 Date Apr. 10, 1986 Sec. 102(e) Date Apr. 10, 1986 PCT Filed Aug. 9, 1985 PCT Pub. No. WO86/01203 PCT Pub. Date Feb. 27, 1986.Compounds of the formula: wherein A means an alkylene; Y-Z means -CH=CH-, -CH2CH2-, or R1 and R2 are each a substituent; R3 is hydrogen atom, alkyl, or alkoxy; R4 is phenyl, phenylalkyl, phenylalkenyl, diphenylmethyl, naphthyl, thiazolyl, optionally substituted pyridyl, optionally substituted pyrimidinyl, quinolyl, benzoylalkyl, benzoyl, furoyl, thenoyl, phenyloxycarbonyl, phenyloxysulfonyl, or phenylsulfonyl; a is 2 or 3, b and c are each 1 or 2, and d is an integer of 0 to 2, provided that the phenyl, phenyl moiety and naphthyl may optionally be substituted, and a pharmaceutically acceptable salt thereof, process for the preparation thereof, and pharmaceutical composition containing the same. The compounds and salt thereof show potent calcium antagonistic activity and are useful for prophylaxis and treatment of hypertension and/or ischemic heart disease.
Bibliography:Application Number: US19860855849