Solubilization of proteins for pharmaceutical compositions using heparin fragments

A pharmaceutical composition is prepared wherein a biologically active conjugated protein which is beta -interferon, interleukin-2, or an immunotoxin is dissolved in an aqueous carrier medium without the presence of a solubilizing agent. The unconjugated protein, which is poorly or not at all water-...

Full description

Saved in:
Bibliographic Details
Main Authors MORELAND; MARGARET, NITECKI; DANUTE E
Format Patent
LanguageEnglish
Published 17.05.1988
Edition4
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

More Information
Summary:A pharmaceutical composition is prepared wherein a biologically active conjugated protein which is beta -interferon, interleukin-2, or an immunotoxin is dissolved in an aqueous carrier medium without the presence of a solubilizing agent. The unconjugated protein, which is poorly or not at all water-soluble at pH 6-8 without such solubilizing agent, is selectively conjugated to at least one heparin fragment having a terminal 2,5-anhydro-D-mannose residue which has an aldehyde not involved in intramolecular hemiacetal formation.
Bibliography:Application Number: US19860879456