Thiazolidine derivatives, process for the preparation and pharmaceutical compositions thereof

New thiazolidine compounds of the formula (I) having anti-ulcer activity are disclosed: (I) wherein Ar is a 2-furyl or a phenyl, naphthyl or pyridyl group optionally substituted by one or more C1-4-alkyl, C1-4-alkoxy, halo-C1-4-alkoxy, dihalomethyl, trihalomethyl, hydroxyl or nitro groups or by a gr...

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Main Authors TETENYI; PETER, MATUZ; JUDIT, HARSANYI; KALMAN, DOMANY; GYOERGY, PALLAGI; KATALIN, EZER; ELEMER, SZPORNY; LASZLO, HEGEDUES; BELA, SZABADKAI; ISTVAN
Format Patent
LanguageEnglish
Published 07.10.1986
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:New thiazolidine compounds of the formula (I) having anti-ulcer activity are disclosed: (I) wherein Ar is a 2-furyl or a phenyl, naphthyl or pyridyl group optionally substituted by one or more C1-4-alkyl, C1-4-alkoxy, halo-C1-4-alkoxy, dihalomethyl, trihalomethyl, hydroxyl or nitro groups or by a group of the formula (II), (II) wherein Y is nitrogen or CH; Z is cyano or carbamoyl if Y is nitrogen, and represents a nitro group if Y is CH. Also disclosed are several processes for preparing the new compounds as well as pharmaceutical compositions and method of treatment employing same.
Bibliography:Application Number: US19840590486