Anti-leukemic beta-glycosyl C-nucleosides

Beta-glycosyl C-nucleoside compounds showing growth inhibitory activity against leukemic cells, of the following formula, are provided: wherein X is NR10, S or O R10 is H or alkyl with 1 to 6 carbon atoms. wherein R6, R7 and R8 are independently selected from H or alkyl of 1 to 6 carbon atoms; or wh...

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Bibliographic Details
Main Authors KLEIN; ROBERT S, BURCHENAL; JOSEPH H, LIM; MUILL, REN; WUYUN
Format Patent
LanguageEnglish
Published 22.04.1986
Edition4
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Beta-glycosyl C-nucleoside compounds showing growth inhibitory activity against leukemic cells, of the following formula, are provided: wherein X is NR10, S or O R10 is H or alkyl with 1 to 6 carbon atoms. wherein R6, R7 and R8 are independently selected from H or alkyl of 1 to 6 carbon atoms; or wherein R16, R11 and R12 are independently selected from H or alkyl of 1-6 carbon atoms; R3 is OH, SR13, or OR9; R4 is OH, SR14, or OR15; R9, R13, R14 and R15 are individually selected from C1-C6 alkyl and C1 to C6 acyl; R5 is OH or H, R'5 is OH or H with the provison that at least one of R5 or R'5 is H; excluding 2-deazoxoformycin; and HCl salts thereof.
Bibliography:Application Number: US19840595637