Polymeric active methylene compounds

• Main Authors: WANG; PATRICIA C, DAWSON; DANIEL J
• Format: Patent
• Language: English
• Published: 18.12.1984
• Edition: 3
• Subjects: CHEMISTRY; COMPOSITIONS BASED THEREON; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS; METALLURGY; ORGANIC MACROMOLECULAR COMPOUNDS; TECHNICAL SUBJECTS COVERED BY FORMER USPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ARTCOLLECTIONS [XRACs] AND DIGESTS; THEIR PREPARATION OR CHEMICAL WORKING-UP

Polymeric compounds which have recurring units, wherein X is N or O, R1, R2 and R3 are hydrogens or lower alkyls and R4 is and aromatic amine or an aromatic hydrazine which provides X as N. These polymers provide active methylene groups which serve as points of attachment for organic groups-particularly azo functionality-containing groups. These azo links can be cleaved by bacteria in the mammalian lower bowel, thereby releasing the corresponding amino groups. This mechanism can effect programmed delivery of pharmaceutically desirable species to the lower bowel.