Synthetic analogues of alpha -melanotropin

Cyclic analogues of the tridecapeptide hormone, alpha -melanotropin. ( alpha -melanocyte stimulating hormone, alpha -MSH), wherein a physiologically stable intramolecular interaction exists (1) between the amino acid residue at position 4 and an amino acid residue at position 10 or 11, and/or (2) be...

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Bibliographic Details
Main Authors HRUBY; VICTOR J, SAWYER; TOMI K, HADLEY; MAC E
Format Patent
LanguageEnglish
Published 27.11.1984
Subjects
CHEMISTRY
GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC
GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TECHNICAL SUBJECTS COVERED BY FORMER USPC
TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ARTCOLLECTIONS [XRACs] AND DIGESTS
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Summary:Cyclic analogues of the tridecapeptide hormone, alpha -melanotropin. ( alpha -melanocyte stimulating hormone, alpha -MSH), wherein a physiologically stable intramolecular interaction exists (1) between the amino acid residue at position 4 and an amino acid residue at position 10 or 11, and/or (2) between the amino acid residue at position 5 and an amino acid residue at position 10 or 11. Preferred analogues, e.g., [half-Cys4, half-Cys10]- alpha -MSH display greatly increased in vitro potency, prolongation, and resistance to enzymatic degradation.
Bibliography:Application Number: US19820387424