Unsymmetrical azetidinone aldehyde disulfides and process

Aryl 4R[1-(2-N-3-methyl-4-al-Z-but-2-ene-oate)-2-oxo-3s-acylamino azetidinone]disulfides are prepared by reacting the corresponding 7 alpha -acylamino-2 alpha -alkoxy-3-methyl-3-cephem-4-carboxylates first with either phenylsulfenyl chloride or a monosubstituted-phenylsulfenyl chloride where the sub...

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Bibliographic Details
Main Authors PFEIL; JANICE L, KUKOLJA; STJEPAN
Format Patent
LanguageEnglish
Published 04.10.1983
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Aryl 4R[1-(2-N-3-methyl-4-al-Z-but-2-ene-oate)-2-oxo-3s-acylamino azetidinone]disulfides are prepared by reacting the corresponding 7 alpha -acylamino-2 alpha -alkoxy-3-methyl-3-cephem-4-carboxylates first with either phenylsulfenyl chloride or a monosubstituted-phenylsulfenyl chloride where the substituent is either chloro, methoxy, methyl or acetoxy. The disulfide compounds produced in this invention are intermediates in the synthesis of the 7 beta -acylamino-7 alpha -alkoxy-3-methyl 1-oxa beta -lactam acids, a class of antibiotic compounds.
Bibliography:Application Number: US19810290919