8-Aza-16,16-difluoroprostanoids

Biologically active 8-aza-16,16-difluoroprostanoids having the formula: wherein A is CH=CH (cis or trans), C 3BOND C, or CH2CH2; R is H, C1-C12 n-alkyl, branched chain alkyl, or cycloalkyl, or a physiologically acceptable metal or amine salt cation; R1 is H, CH3, or C2H5; R2 is CH3, CF3, phenyl, or...

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Bibliographic Details
Main Author SCRIBNER; RICHARD M
Format Patent
LanguageEnglish
Published 16.03.1982
Subjects
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Biologically active 8-aza-16,16-difluoroprostanoids having the formula: wherein A is CH=CH (cis or trans), C 3BOND C, or CH2CH2; R is H, C1-C12 n-alkyl, branched chain alkyl, or cycloalkyl, or a physiologically acceptable metal or amine salt cation; R1 is H, CH3, or C2H5; R2 is CH3, CF3, phenyl, or mono- or disubstituted phenyl, the phenyl substituents being selected from the group F, Cl, CH3, OCH3, NO2, and CF3; n is an integer from 3 to 8 when R2 is CH3 or CF3, or from 0 to 2 when R2 is phenyl or substituted phenyl; as racemic stereo isomer mixtures, or single or mixed optically-active stereo isomers.
Bibliography:Application Number: US19800176784