6(R)-[2-(8-Hydroxy-2,6-dimethylpolyhydronaphthyl-1)-ethyl]-4(R)-hydroxy-3,4,5,6-tetrahydro-2H-pyran-2-ones

The title compounds are prepared by saponifying the corresponding 8-acyloxy compounds, with strong base at elevated temperatures to remove the hindered acyl group without disrupting the rest of the molecule. The products are useful as intermediates in the synthesis of antihypercholesterolemia agents...

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Bibliographic Details
Main Author WILLARD; ALVIN K
Format Patent
LanguageEnglish
Published 06.10.1981
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The title compounds are prepared by saponifying the corresponding 8-acyloxy compounds, with strong base at elevated temperatures to remove the hindered acyl group without disrupting the rest of the molecule. The products are useful as intermediates in the synthesis of antihypercholesterolemia agents.
Bibliography:Application Number: US19800175232