1 alpha -hydroxy-25-keto-27-nor-cholecalciferol and processes for preparing same

The invention provides new vitamin D derivatives as well as new intermediate compounds derived during the processes for preparing such new derivatives. The new derivatives have been identified as 1 alpha -hydroxy-25-keto-27-nor-vitamin D3 and its acylates. 1 alpha -hydroxy-25-keto-27-nor-vitamin D3...

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Bibliographic Details
Main Authors NAPOLI, JR.; JOSEPH L, FIVIZZANI; MARY A, DELUCA; HECTOR F, SCHNOES; HEINRICH K
Format Patent
LanguageEnglish
Published 28.04.1981
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
STEROIDS
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Summary:The invention provides new vitamin D derivatives as well as new intermediate compounds derived during the processes for preparing such new derivatives. The new derivatives have been identified as 1 alpha -hydroxy-25-keto-27-nor-vitamin D3 and its acylates. 1 alpha -hydroxy-25-keto-27-nor-vitamin D3 expresses excellent vitamin D-like activity and would find ready application as a substitute for vitamin D compounds in the treatment of disease states evincing calcium-phosphorous imbalance.
Bibliography:Application Number: US19790041081