Process for the production of 6-substituted 4-methyl-2-pyridones

Process for the production of 6-substituted-4-methyl-2-pyridones having the formula: wherein R is a branched or unbranched alkyl group, a halogenated branched or unbranched alkyl group or a substituted or unsubstituted aryl group. Senecioic acid amide having the formula: is reacted in a solvent at a...

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Bibliographic Details
Main Author MICHEL, URS
Format Patent
LanguageEnglish
Published 27.05.1980
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Process for the production of 6-substituted-4-methyl-2-pyridones having the formula: wherein R is a branched or unbranched alkyl group, a halogenated branched or unbranched alkyl group or a substituted or unsubstituted aryl group. Senecioic acid amide having the formula: is reacted in a solvent at an elevated temperature in the presence of a Lewis acid (as a catalyst) with an acyl chloride having the formula: wherein R has the same meaning as above. The reaction mixture is subsequently placed in an aqueous phase for hydrolysis. The 6-substituted-4-methyl-2-pyridone is separated by extraction through the buffering of the reaction mixture at a pH of 4 to 5.
Bibliography:Application Number: US19790002594