Cyclization of cysteine-containing peptides

The synthesis of a disulfide cyclic peptide by preparing peptide containing at least two cysteine moieties in its amino acid chain one of which is protected by an n-alkylthio group, and subjecting such peptide to a procedure in which the peptide is held in solution substantially free of oxygen at a...

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Bibliographic Details
Main Authors HUGHES; JOHN LAWRENCE, LIU; ROBERT CHUNG-HUANG, SEYLER; JAY KENNETH
Format Patent
LanguageEnglish
Published 30.12.1975
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC
GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TECHNICAL SUBJECTS COVERED BY FORMER USPC
TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ARTCOLLECTIONS [XRACs] AND DIGESTS
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Summary:The synthesis of a disulfide cyclic peptide by preparing peptide containing at least two cysteine moieties in its amino acid chain one of which is protected by an n-alkylthio group, and subjecting such peptide to a procedure in which the peptide is held in solution substantially free of oxygen at a pH of from about 5 to 10 until rearrangement takes place to yield a cyclic disulfide peptide and to displace said n-alkylthio group from said amino acid chain. The disclosure also embraces said non-cyclic peptides as new compounds and the processes by which they are perpared.
Bibliography:Application Number: US19740505344