Chromic acid oxidation of vinblastine sulfate to form vincristine

• Main Authors: JOVANOVICS; KAROLINA, SZASZ; KALMAN, BITTNER; EMIL, DEZSERI; ESZTER, FEKETE; GYORGY, ELES; JANOS
• Format: Patent
• Language: English
• Published: 12.08.1975
• Subjects: CHEMISTRY; HETEROCYCLIC COMPOUNDS; METALLURGY; ORGANIC CHEMISTRY

Vincristine is prepared in a semisynthetic process starting from vinblastine. Vinblastine or a salt thereof, preferably the sulphate, is oxidized with chromic acid or with one of its salts at a low temperature, the reaction mixture is neutralized or rendered alkaline and the product is separated the...