Chromic acid oxidation of vinblastine sulfate to form vincristine

Vincristine is prepared in a semisynthetic process starting from vinblastine. Vinblastine or a salt thereof, preferably the sulphate, is oxidized with chromic acid or with one of its salts at a low temperature, the reaction mixture is neutralized or rendered alkaline and the product is separated the...

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Bibliographic Details
Main Authors JOVANOVICS; KAROLINA, SZASZ; KALMAN, BITTNER; EMIL, DEZSERI; ESZTER, FEKETE; GYORGY, ELES; JANOS
Format Patent
LanguageEnglish
Published 12.08.1975
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Vincristine is prepared in a semisynthetic process starting from vinblastine. Vinblastine or a salt thereof, preferably the sulphate, is oxidized with chromic acid or with one of its salts at a low temperature, the reaction mixture is neutralized or rendered alkaline and the product is separated therefrom by extraction, the extract is evaporated to dryness, the dry residue is optionally formylated, vincristine, and optionally N-demethylvinblastine too, are isolated from the product, and the product(s) are optionally converted into their salts, preferably into the sulphates.
Bibliography:Application Number: US19720319468