4(2-(ALPHA-METHYL-PHENETHYLAMINO)-ETHOXY)-BENZENES

• Main Author: PINHAS H,FR
• Format: Patent
• Language: English
• Published: 22.10.1974
• Subjects: ACYCLIC OR CARBOCYCLIC COMPOUNDS; CHEMISTRY; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

1365097 Substituted phenoxyalkylamines LABORATOIRES LAROCHE NAVARRON 17 Dec 1971 [28 Dec 1970] 58751/71 Heading C2C Novel compounds of Formula I: in which R 1 is hydrogen, halogen, an alkyl group or an alkoxy group, A is an alkyl, alkylaryl, cycloalkyl, alkenyl, cycloalkenyl group or a group in which R2 is an alkyl or alkoxyalkyl group and R 3 is an alkyl, cycloalkyl or aryl group, and their acid addition salts, are prepared by reacting the compounds of Formula II or III: in which A 1 represents an A group or the group -COR 4 or -CHOHR 3 , X is halogen, R 1 , R 3 and A have the meanings defined in claim 1, R 4 is alkyl, and, when A 1 is not an A- group, converting said group to an A group by heating the condensation product in an alcoholic medium in the presence of hydrogen chloride or by dehydrating it by treatment with an acid or base in the case when A 1 is -CHOHR 3 or by reducing the condensation product by treatment with zinc and hydrochloric acid when A 1 is -COR 4 . p-Propyl- or p-heptyl-phenyl 2-bromoethyl ethers are prepared by reaction of 1,2-dibromoethane and the appropriate phenol. Pharmaceutical compositions in conventional forms for example, oral administration, and having coronary, vasodilatory, cardiotonic and spasmolytic activity comprise an above novel compound and a carrier or excipient.