THERAPEUTICALLY USEFUL COMPOUND,LEUPEPTINS,AND PROCESSES FOR THE PREPARATION THEREOF

• Main Authors: UMEZAWA H,JA, TAKEUCHI T,JA, MAEDA K,JA, HAMADA M,JA, AOYAGI T,JA, HARA T,JA
• Format: Patent
• Language: English
• Published: 08.10.1974
• Edition: 2
• Subjects: BEER; BIOCHEMISTRY; CHEMISTRY; ENZYMOLOGY; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; MICROBIOLOGY; MUTATION OR GENETIC ENGINEERING; ORGANIC CHEMISTRY; PEPTIDES; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES; SPIRITS; VINEGAR; WINE

1,268,212. Enzyme-inhibitor compositions. ZAIDAN HOJIN BISEIBUTSU KAGAKU KENKYU KAI. 10 April, 1969 [19 April, 1968, 25 March, 1969], No. 18421/69. Heading A5B. '[Also in Division C2] Pharmaceutical compositions which inhibit the enzymatic reactions of trypsin, papain, kallikrein, plasmin and thrombokinase, which inhibit fibrinolysis, kinin formation from kininogen and blood coagulation and which are useful as anti-inflammatory agents comprise a compound I R 3 CONH-CH(R 2 )-CONH-CH(R 1 )- CONH-CH(CHO)-(CH 2 ) 3 -NHC=(NH)NH 2 wherein R 1 and R 2 are CH(CH 3 ) 2 , CH 2 CH (CH 3 ) 2 or -CH(CH 3 )CH 2 CH 3 and R 3 is CH 3 of C 2 H 5 , and optionally antihistamines, sulpha drugs, liptropic agents, CNS stimulants, local anaesthetics, analgesics, laxatixes, sedatives, antibiotics, vitamins, hormones, anabolic agents and/or antifungal agents. Specific examples of which are mentioned. The compositions may be administered orally, parenterally or topically.