PREPARATION OF-2-ALKOXY-4-HYDROXYPYRIMIDINES

1336138 Preparation of 2-alkoxy-4-hydroxy pyrimidines IMPERIAL CHEMICAL INDUSTRIES Ltd 2 Dec 1970 [10 Dec 1969] 60324/69 Heading C2C 2 - Alkoxy - 4 - hydroxy - pyrimidines, or salts thereof, of the formula are obtained by reacting an O-alkyl isourea of formula H 2 N-C(OR) : NH in the presence of a b...

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Bibliographic Details
Main Author BOWDEN R,GB
Format Patent
LanguageEnglish
Published 11.09.1973
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:1336138 Preparation of 2-alkoxy-4-hydroxy pyrimidines IMPERIAL CHEMICAL INDUSTRIES Ltd 2 Dec 1970 [10 Dec 1969] 60324/69 Heading C2C 2 - Alkoxy - 4 - hydroxy - pyrimidines, or salts thereof, of the formula are obtained by reacting an O-alkyl isourea of formula H 2 N-C(OR) : NH in the presence of a base with a crotonic ester of the formula R 6 -C(X) : C(R 5 )-COOR1 wherein R, R1, R 5 and R 6 are C 1-8 alkyl groups and X is an amino radical derived from an amine of formula R11R111NH, wherein R11 and R111 are alkyl, aryl or aralkyl group, or an amino radical derived from a cyclic secondary amine. The reaction may be carried out in solution in an alkanol, preferred bases being alkali metal carbonates and alkoxides. The crotonic ester starting materials may be prepared by reacting a secondary amine of the formula R11R111NH with an appropriate beta-keto ester.
Bibliography:Application Number: USD3758472