1-LOWER ALKYL-4-(2'-HYDROXYLOWER ALKYL)-4-PIPERIDINOLS AND LOWER ALKYL ACID ESTERS THEREOF

Novel tetrahydropyridine derivatives of the formula <FORM:1117041/C2/1> wherein R1 represents a C1- 4 alkyl radica or the allyl radical and R2 represents a C1- 4 alkyl radical or the phenyl radical, and their salts with inorganic or organic acids, are obtained by partially reducing (1) the cor...

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Bibliographic Details
Main Authors ROLF DENSS, HUGO RYF, HANS HERBERT KUHNIS
Format Patent
LanguageEnglish
Published 07.04.1970
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:Novel tetrahydropyridine derivatives of the formula <FORM:1117041/C2/1> wherein R1 represents a C1- 4 alkyl radica or the allyl radical and R2 represents a C1- 4 alkyl radical or the phenyl radical, and their salts with inorganic or organic acids, are obtained by partially reducing (1) the corresponding ketones or (2) pyridinium compounds of the formula <FORM:1117041/C2/2> wherein X(-) represents the hydroxyl ion, a monovalent anion or the normal equivalent of a polyvalent anion, and, if desired, converting the product into a salt with an inorganic or organic acid. The pyridinium compound (2) may be obtained by quaternization of the corresponding pyridyl ketone with an ester R1X. Therapeutic compositions having antitussive and analgetic properties contain as the active ingredient the above tetrahydropyridine derivatives or their pharmaceutically acceptable salts. The antitussive composition may be in a form suitable for oral or parenteral application. Reference has been directed by the Comptroller to Specification 1,062,715.
Bibliography:Application Number: USD3505343