Method for preparing 6belta-19-oxidosteroids
6b ,19-Oxido-steroids are prepared by treating 6b -hydroxy-10-methyl steroids with an oxidative metal acylate in the presence of iodine and under the influence of a free-radical initiator. Suitable initiators are azo compounds and peroxides, the former preferably having the formula: <FORM:0944268...
Saved in:
| Main Author | |
|---|---|
| Format | Patent |
| Language | English |
| Published |
27.10.1964
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | 6b ,19-Oxido-steroids are prepared by treating 6b -hydroxy-10-methyl steroids with an oxidative metal acylate in the presence of iodine and under the influence of a free-radical initiator. Suitable initiators are azo compounds and peroxides, the former preferably having the formula: <FORM:0944268/C2/1> (wherein R1 and R2 are hydrogen, or R1, R2, R3 and R4 are the same or different alkyl or aralkyl groups, or R1 and R2 and/or R3 and R4 together form a cycloalkyl group). Suitable acylates are lead tetraacylates and silver and mercury acylates, and the reaction may be performed in an organic solvent to which is preferably added a weak base. Steroids of the androstane, pregnane, cholane, cholestane and spirostane series may be used, particularly important being those saturated in ring A and possibly containing a 5-halogen atom. Examples are given. U.S.A. Specification 3,067,198 is referred to. |
|---|---|
| AbstractList | 6b ,19-Oxido-steroids are prepared by treating 6b -hydroxy-10-methyl steroids with an oxidative metal acylate in the presence of iodine and under the influence of a free-radical initiator. Suitable initiators are azo compounds and peroxides, the former preferably having the formula: <FORM:0944268/C2/1> (wherein R1 and R2 are hydrogen, or R1, R2, R3 and R4 are the same or different alkyl or aralkyl groups, or R1 and R2 and/or R3 and R4 together form a cycloalkyl group). Suitable acylates are lead tetraacylates and silver and mercury acylates, and the reaction may be performed in an organic solvent to which is preferably added a weak base. Steroids of the androstane, pregnane, cholane, cholestane and spirostane series may be used, particularly important being those saturated in ring A and possibly containing a 5-halogen atom. Examples are given. U.S.A. Specification 3,067,198 is referred to. |
| Author | SZPILFOGEL STEFAN ANTONI |
| Author_xml | – fullname: SZPILFOGEL STEFAN ANTONI |
| BookMark | eNrjYmDJy89L5WTQ8U0tychPUUjLL1IoKEotSCzKzEtXMEtKzSlJ1DW01M2vyEzJLy5JLcrPTCnmYWBNS8wpTuWF0twM8m6uIc4euqkF-fGpxQWJyal5qSXxocHGhqYmpiaGjsaEVQAAuokqiw |
| ContentType | Patent |
| DBID | EVB |
| DatabaseName | esp@cenet |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: EVB name: esp@cenet url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP sourceTypes: Open Access Repository |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Chemistry Sciences |
| ExternalDocumentID | US3154541A |
| GroupedDBID | EVB |
| ID | FETCH-epo_espacenet_US3154541A3 |
| IEDL.DBID | EVB |
| IngestDate | Fri Jul 19 15:14:20 EDT 2024 |
| IsOpenAccess | true |
| IsPeerReviewed | false |
| IsScholarly | false |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-epo_espacenet_US3154541A3 |
| Notes | Application Number: US19620202987 |
| OpenAccessLink | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19641027&DB=EPODOC&CC=US&NR=3154541A |
| ParticipantIDs | epo_espacenet_US3154541A |
| PublicationCentury | 1900 |
| PublicationDate | 19641027 |
| PublicationDateYYYYMMDD | 1964-10-27 |
| PublicationDate_xml | – month: 10 year: 1964 text: 19641027 day: 27 |
| PublicationDecade | 1960 |
| PublicationYear | 1964 |
| RelatedCompanies | ORGANON INC |
| RelatedCompanies_xml | – name: ORGANON INC |
| Score | 2.3219354 |
| Snippet | 6b ,19-Oxido-steroids are prepared by treating 6b -hydroxy-10-methyl steroids with an oxidative metal acylate in the presence of iodine and under the influence... |
| SourceID | epo |
| SourceType | Open Access Repository |
| SubjectTerms | CHEMISTRY METALLURGY ORGANIC CHEMISTRY STEROIDS |
| Title | Method for preparing 6belta-19-oxidosteroids |
| URI | https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19641027&DB=EPODOC&locale=&CC=US&NR=3154541A |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV3dS8MwED_mFPVNpzK_-yB9smjXrGkeiri2Ywj7wG2yt5E0iQ5kLW1F_3yTuKkvewkhgUty8Lu7XHJ3ADfUQynibc_BwpUOalPuBLppMUm8lDFGjSu7P_B7U_Q0a89q8LaOhTF5Qj9NckSFqFThvTLyOv9zYsXmb2V5xxZqKHvoTsLY5j_hYj5S-hLbcSdMRsN4GNlRFE7H9uA59LSpgNzHLdhWRjTWWEheOjomJf-vULoHsDNStJbVIdTEsgF70bruWgN2-6vnbtVdIa88gtu-KfVsKRvTyguhawcuXy2fifeKOi5xsq8F1_EaRbbg5TFcd5NJ1HPUsvPfE86n4_X-vBOoq3u_aILlcox8GeBUqXhEaRpI7BLJfEIkJ_RenEJzE5WzzVPnsK_5pMVvC19AvSo-xKXSqxW7Miz5BqCMfe8 |
| link.rule.ids | 230,309,783,888,25576,76876 |
| linkProvider | European Patent Office |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV3dT8IwEL8gGvFNUYOf7MHsyUXHyro9LEY2lqkMiIDhjbRrp0sMW2BG_3zbCuoLL03TJtf2kt_d9dq7A7giFkoQa1sG5mZqoDZhhiObFk1dK6GUEuXKjvt2NEGP0_a0Am_rWBiVJ_RTJUcUiEoE3kslr4s_J1ag_lYub2gmhvK7cOwFOvsJF7OR0JdYDzpedzgIBr7u-95kpPefPUuaCsi834JtYWBjiYXuS0fGpBT_FUq4DztDQWteHkCFz-tQ89d11-qwG6-eu0V3hbzlIVzHqtSzJmxMrVhwWTtw_qrZlL-XxDBdI__KmIzXWOQZWx5BM-yO_cgQy85-TzibjNb7s46hKu79vAGayTCyUwcnQsUjQhInxaabUtt1U-aSW34CjU1UTjdPNaEWjePerPfQfzqDPckzKYpb-Byq5eKDXwgdW9JLxZ5vsquA4g |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=Method+for+preparing+6belta-19-oxidosteroids&rft.inventor=SZPILFOGEL+STEFAN+ANTONI&rft.date=1964-10-27&rft.externalDBID=A&rft.externalDocID=US3154541A |