ANTI-ALARMIN BINDING MOLECULES AND TREATMENT OF PNEUMONITIS

The present disclosure provides methods and compositions for the treatment of pneumonitis (including checkpoint inhibitor induced pneumonitis), fibrosis, and type 2 inflammatory disorders comprising administering anti-alarmin binding molecules to a subject in need thereof. In son embodiments treatme...

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Bibliographic Details
Main Authors WHITE, Daniel, SWANSON, Sven, NIKOLINOKOS, Petros, JACKSON, Crystal
Format Patent
LanguageEnglish
Published 29.05.2025
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:The present disclosure provides methods and compositions for the treatment of pneumonitis (including checkpoint inhibitor induced pneumonitis), fibrosis, and type 2 inflammatory disorders comprising administering anti-alarmin binding molecules to a subject in need thereof. In son embodiments treatment comprises administering one or more checkpoint inhibitors conjugated to a therapeutic moiety comprising a cytotoxic agent, a therapeutic agent, a radioisotope, an ultrasound sensitizer, or an exosome secretion inhibitor.
Bibliography:Application Number: US202318841520