PEPTIDE HYDROGEL COMPRISING HYDROPHILIC AZIDE-CONTAINING AMINO ACID AND ITS USE

Provided herein is a novel β-hairpin peptide hydrogel that can be labeled with contrast agent for CECT imaging. The β-hairpin peptide hydrogel undergoes shear-thinning upon application of shear stress, and rheological recovery upon removal of the shear stress, and therefore is well-suited for delive...

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Bibliographic Details
Main Authors Xie, Yixin, Schneider, Joel, Lopez-Silva, Tania
Format Patent
LanguageEnglish
Published 02.01.2025
Subjects
AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F,C08G
CHEMISTRY
COMPOSITIONS BASED THEREON
GENERAL PROCESSES OF COMPOUNDING
METALLURGY
ORGANIC CHEMISTRY
ORGANIC MACROMOLECULAR COMPOUNDS
PEPTIDES
THEIR PREPARATION OR CHEMICAL WORKING-UP
WORKING-UP
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Summary:Provided herein is a novel β-hairpin peptide hydrogel that can be labeled with contrast agent for CECT imaging. The β-hairpin peptide hydrogel undergoes shear-thinning upon application of shear stress, and rheological recovery upon removal of the shear stress, and therefore is well-suited for delivery by syringe to a target location in a subject. Once delivered, the labeled β-hairpin peptide hydrogel remains in place to allow CECT imaging of the target location in the subject, which can be used to guide administration of further agents to the target location.
Bibliography:Application Number: US202318340863