ISOLATED MONOCLONAL ANTIBODY, ISOLATED ANTIGEN BINDING FRAGMENT THEREOF, COMPOSITION, METHOD OF ELICITING IMMUNE RESPONSE AGAINST ANTIGENIC EPITOPE OF FLAVIVIRUS IN SUBJECT, METHOD FOR DETECTING FLAVIVIRUS, POLYPEPTIDE, AND ANTIBODY-CELL CONJUGATION
An isolated monoclonal antibody includes a heavy chain variable domain (VH) and a light chain variable domain (VL). The VH includes a heavy chain complementary determining region (HCDR)1 of SEQ ID NO: 1, a HCDR2 of SEQ ID NO: 2, and HCDR3 of SEQ ID NO: 3. The VL includes a light chain complementary...
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| Format | Patent |
| Language | English |
| Published |
07.11.2024
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| Abstract | An isolated monoclonal antibody includes a heavy chain variable domain (VH) and a light chain variable domain (VL). The VH includes a heavy chain complementary determining region (HCDR)1 of SEQ ID NO: 1, a HCDR2 of SEQ ID NO: 2, and HCDR3 of SEQ ID NO: 3. The VL includes a light chain complementary determining region (LCDR)1 of SEQ ID NO: 4, a LCDR2 having an amino acid sequence of SAR, and a LCDR3 of SEQ ID NO: 5. The isolated monoclonal antibody specifically binds to a glycosylated envelope (E) protein of a flavivirus and neutralizes the flavivirus. |
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| AbstractList | An isolated monoclonal antibody includes a heavy chain variable domain (VH) and a light chain variable domain (VL). The VH includes a heavy chain complementary determining region (HCDR)1 of SEQ ID NO: 1, a HCDR2 of SEQ ID NO: 2, and HCDR3 of SEQ ID NO: 3. The VL includes a light chain complementary determining region (LCDR)1 of SEQ ID NO: 4, a LCDR2 having an amino acid sequence of SAR, and a LCDR3 of SEQ ID NO: 5. The isolated monoclonal antibody specifically binds to a glycosylated envelope (E) protein of a flavivirus and neutralizes the flavivirus. |
| Author | YANG, Hui-Hua CHEN, Li-Kuang CHIN, Chuan |
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| Snippet | An isolated monoclonal antibody includes a heavy chain variable domain (VH) and a light chain variable domain (VL). The VH includes a heavy chain complementary... |
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| SubjectTerms | CHEMISTRY INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES MEASURING METALLURGY ORGANIC CHEMISTRY PEPTIDES PHYSICS TESTING |
| Title | ISOLATED MONOCLONAL ANTIBODY, ISOLATED ANTIGEN BINDING FRAGMENT THEREOF, COMPOSITION, METHOD OF ELICITING IMMUNE RESPONSE AGAINST ANTIGENIC EPITOPE OF FLAVIVIRUS IN SUBJECT, METHOD FOR DETECTING FLAVIVIRUS, POLYPEPTIDE, AND ANTIBODY-CELL CONJUGATION |
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