ISOLATED MONOCLONAL ANTIBODY, ISOLATED ANTIGEN BINDING FRAGMENT THEREOF, COMPOSITION, METHOD OF ELICITING IMMUNE RESPONSE AGAINST ANTIGENIC EPITOPE OF FLAVIVIRUS IN SUBJECT, METHOD FOR DETECTING FLAVIVIRUS, POLYPEPTIDE, AND ANTIBODY-CELL CONJUGATION

An isolated monoclonal antibody includes a heavy chain variable domain (VH) and a light chain variable domain (VL). The VH includes a heavy chain complementary determining region (HCDR)1 of SEQ ID NO: 1, a HCDR2 of SEQ ID NO: 2, and HCDR3 of SEQ ID NO: 3. The VL includes a light chain complementary...

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Bibliographic Details
Main Authors CHEN, Li-Kuang, CHIN, Chuan, YANG, Hui-Hua
Format Patent
LanguageEnglish
Published 07.11.2024
Subjects
CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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Summary:An isolated monoclonal antibody includes a heavy chain variable domain (VH) and a light chain variable domain (VL). The VH includes a heavy chain complementary determining region (HCDR)1 of SEQ ID NO: 1, a HCDR2 of SEQ ID NO: 2, and HCDR3 of SEQ ID NO: 3. The VL includes a light chain complementary determining region (LCDR)1 of SEQ ID NO: 4, a LCDR2 having an amino acid sequence of SAR, and a LCDR3 of SEQ ID NO: 5. The isolated monoclonal antibody specifically binds to a glycosylated envelope (E) protein of a flavivirus and neutralizes the flavivirus.
Bibliography:Application Number: US202318312737