SPATIALLY CO-REGISTERED GENOMIC AND IMAGING (SCORGI) DATA ELEMENTS FOR FINGERPRINTING MICRODOMAINS

• Main Authors: STERN, ANDREW M, CHENNUBHOTLA, SRINIVAS C, TAYLOR, DOUGLASS L, GOUGH, ALBERT H, BECICH, MICHAEL J
• Format: Patent
• Language: English
• Published: 10.10.2024
• Subjects: CALCULATING; CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE; COMPUTING; COUNTING; ELECTRIC DIGITAL DATA PROCESSING; IMAGE DATA PROCESSING OR GENERATION, IN GENERAL; INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTEDFOR SPECIFIC APPLICATION FIELDS; INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES; MEASURING; PERFORMING OPERATIONS; PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL; PHYSICS; TESTING; TRANSPORTING

A method of generating a plurality of spatially co-registered data elements, each spatially co-registered data element being associated with and generated from a pair of co-registered tissue sections obtained from adjacent positions of a core taken from a tissue sample and including an image data section and a genomic data section. The method includes, for each pair of co-registered tissue sections: (i) obtaining and storing as part of a data element a plurality of multi to hyperplexed images from the imaging data section of the co-registered tissue section, (ii) generating and storing as part of the data element image data from the plurality of multi to hyperplexed images, and (iii) generating and storing as part of the data element genomic data from the genomic data section of the associated co-registered tissue section.