APOL1 INHIBITORS AND METHODS OF USE

Provided herein are compounds of formula (A′): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, X3, X4, Ra, Rb, Rc, L, Q, and Y are as defined herein. Also provided are methods of N inhibiting APOL1 and methods of preparing compoun...

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Main Authors ZHANG, Birong, LEE, Patrick Sang Tae, HOEK, Maarten, REID, Adam Neil, ASSIMON, Victoria Anne, EWING, Todd Jonathan August, MORGANS, Jr., David John, BRONNER, Sarah M, SINZ, Christopher Joseph
Format Patent
LanguageEnglish
Published 26.09.2024
Subjects
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Provided herein are compounds of formula (A′): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein X1, X2, X3, X4, Ra, Rb, Rc, L, Q, and Y are as defined herein. Also provided are methods of N inhibiting APOL1 and methods of preparing compounds of formula (A′). Also provided are methods of inhibiting APOL1 and methods of treating an APOL1-mediated disease, disorder, or condition in an individual.
Bibliography:Application Number: US202218277943