METHIONINE ADENOSYLTRANSFERASE 2A INHIBITOR

The present invention provides a methionine adenosyltransferase 2A inhibitor. The structure of the methionine adenosyltransferase 2A inhibitor is as represented by general formula (I), and the definitions of substituents are as described in the specification. The present invention further provides a...

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Main Authors TIAN, Zhoushan, WU, Jian, ZHANG, Huan, Zuo, Rui, ZHOU, Qiuhua, DAI, Qingyu, MA, Changyou, ZHU, Chunxia, HUANG, Dandan, MA, Li, XU, Dan, MIAO, Lei, SU, Jincai, Wu, Yebin
Format Patent
LanguageEnglish
Published 29.08.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Abstract The present invention provides a methionine adenosyltransferase 2A inhibitor. The structure of the methionine adenosyltransferase 2A inhibitor is as represented by general formula (I), and the definitions of substituents are as described in the specification. The present invention further provides a preparation method therefor. A compound represented by formula I provided by the present invention has significant methionine adenosyltransferase 2A inhibitory activity, and can be used in the treatment of diseases mediated by overexpression of methionine adenosyltransferase 2A.
AbstractList The present invention provides a methionine adenosyltransferase 2A inhibitor. The structure of the methionine adenosyltransferase 2A inhibitor is as represented by general formula (I), and the definitions of substituents are as described in the specification. The present invention further provides a preparation method therefor. A compound represented by formula I provided by the present invention has significant methionine adenosyltransferase 2A inhibitory activity, and can be used in the treatment of diseases mediated by overexpression of methionine adenosyltransferase 2A.
Author ZHOU, Qiuhua
ZHANG, Huan
Wu, Yebin
MA, Li
XU, Dan
WU, Jian
HUANG, Dandan
TIAN, Zhoushan
Zuo, Rui
SU, Jincai
MIAO, Lei
ZHU, Chunxia
DAI, Qingyu
MA, Changyou
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– fullname: MA, Changyou
– fullname: ZHU, Chunxia
– fullname: HUANG, Dandan
– fullname: MA, Li
– fullname: XU, Dan
– fullname: MIAO, Lei
– fullname: SU, Jincai
– fullname: Wu, Yebin
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Snippet The present invention provides a methionine adenosyltransferase 2A inhibitor. The structure of the methionine adenosyltransferase 2A inhibitor is as...
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SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title METHIONINE ADENOSYLTRANSFERASE 2A INHIBITOR
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