PI3K-ALPHA INHIBITORS AND METHODS OF USE THEREOF

• Main Authors: WALTERS, W. Patrick, PIERCE, Levi CharlesThomas, GIORDANETTO, Fabrizio, LANDAGARAY, Elodie, RAYNOR, Kevin David, BURNIE, Andrew J, VEMULA, Naresh, ATIENZA, Bren-Jordan, OUTIN, Johanne, CHITALE, Sampada, LESCARBEAU, André, LEPITRE, Thomas, DENINNO, Michael Paul, KRUEGER, Elaine B, KURUKULASURIYA, Ravi, MAERTENS, Gaetan, GUNAYDIN, Hakan, BERTRAND-LAPERLE, Megan, DIPIETRO, Lucian V, MCLEAN, Thomas H, FRIDRICH, Cary Griffin, ZHANG, Hanmo, PAN, Yue, MOHAMED, Tarek, THORAT, Rakesh, GELOZIA, Shorena, WANG, Qi, SHORTSLEEVES, Kelley C, PECHERSKY, Yakov, TANG, Yong, STURINO, Claudio, LARIVEE, Alexandre, MADER, Mary M, TAYLOR, Alexander M, BOEZIO, Alessandro, BOUSQUET, Yves, LEE, Jessica, JOBIN-DES LAURIERS, Antoine, PAL, Mohan, GIGUERE, Jean-Benoit, TANVEER, Kashif, CHEN, Fei
• Format: Patent
• Language: English
• Published: 29.08.2024
• Subjects: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM; CHEMISTRY; HETEROCYCLIC COMPOUNDS; HUMAN NECESSITIES; HYGIENE; MEDICAL OR VETERINARY SCIENCE; METALLURGY; ORGANIC CHEMISTRY; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES

The present disclosure relates to novel compounds and pharmaceutical compositions thereof, and methods for inhibiting the activity of PI3K-α enzymes with the compounds and compositions of the disclosure. The present disclosure further relates to, but is not limited to, methods for treating disorders associated with PI3K-α signaling with the compounds and compositions of the disclosure.