LIPID NANOPARTICLE COMPOSITIONS AND USES THEREOF

Provided are methods for delivering lipid nanoparticles (LNPs) to a lung cell of a subject suffering from or at risk for cystic fibrosis (CF), wherein the method comprises nebulizing a liquid pharmaceutical composition to generate an aerosolized pharmaceutical composition, and administering the aero...

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Main Authors Alfaifi, Ali Ahmed, Mohapatra, Sakya Sing, Wustman, Brandon A, Baek, Julia Jung-un, Lockhart, David J, Wang, Yufeng, Ishimaru, Daniella, Li, Shuang, Cefalu, Joseph S, Hennig, Mirko, Kharitonov, Vladimir Grigor'evich
Format Patent
LanguageEnglish
Published 29.08.2024
Subjects
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:Provided are methods for delivering lipid nanoparticles (LNPs) to a lung cell of a subject suffering from or at risk for cystic fibrosis (CF), wherein the method comprises nebulizing a liquid pharmaceutical composition to generate an aerosolized pharmaceutical composition, and administering the aerosolized pharmaceutical composition to the subject, wherein the LNPs comprise mRNA encoding a Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein.
Bibliography:Application Number: US202418593245