SUBSTITUTED AMINO ACIDS AS INTEGRIN INHIBITORS

The invention relates to compounds of formula (I):or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, αvβ1 integrin and αvβ6 integrin that are useful for treating fibrosis suc...

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Main Authors CHA, Jacob, REILLY, Maureen, HOM, Timothy, BAILEY, Christopher, LEFTHERIS, Katerina, MUÑOZ, Manuel, COOPER, Nicole, ZHENG, Yajun, MORGANS, JR., David J, FINKELSTEIN, Darren
Format Patent
LanguageEnglish
Published 15.08.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention relates to compounds of formula (I):or a salt thereof, wherein R1, G, L1, L2, L3, and Y are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are inhibitors of one, or both of, αvβ1 integrin and αvβ6 integrin that are useful for treating fibrosis such as in nonalcoholic steatohepatitis (NASH), idiopathic pulmonary fibrosis (IPF) and nonspecific interstitial pneumonia (NSIP).
Bibliography:Application Number: US202318545952