GENETIC SWITCHES AND THEIR USE IN TREATING CANCER

In certain aspects, the disclosure relates to a nucleic acid molecule encoding a cytokine (e.g., IL-12) and one or more genetic switches encoding thanotransmission polypeptides (e.g., TRIF, Gasdermin E, or variants thereof). Vectors (e.g., engineered viruses, plasmids and transposons), cells and pha...

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Bibliographic Details
Main Authors Dhakal, Sabin, Choi, Yeon Sook, SHALER, Christopher Ryan, Zhang, Xuqing, Hett, Erik Christian
Format Patent
LanguageEnglish
Published 15.08.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:In certain aspects, the disclosure relates to a nucleic acid molecule encoding a cytokine (e.g., IL-12) and one or more genetic switches encoding thanotransmission polypeptides (e.g., TRIF, Gasdermin E, or variants thereof). Vectors (e.g., engineered viruses, plasmids and transposons), cells and pharmaceutical compositions comprising one or more nucleic acid molecules encoding one or more thanotransmission polypeptides are also disclosed. Methods of promoting thanotransmission by a target cell, methods of promoting an immune response in a subject, and methods of treating cancer in a subject are further disclosed.
Bibliography:Application Number: US202418408550