DISPIROPYRROLIDINE DERIVATIVES

A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interacti...

Full description

Saved in:
Bibliographic Details
Main Authors Wakabayashi, Takanori, Miyazaki, Masaki, Taniguchi, Toru, Yoshida, Shoko, Yoshida, Keisuke, Uoto, Kouichi, Setoguchi, Masaki, Yamaguchi, Akitake, Sugimoto, Yuuichi
Format Patent
LanguageEnglish
Published 25.07.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Online AccessGet full text

Cover

Abstract A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
AbstractList A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
Author Yoshida, Shoko
Yoshida, Keisuke
Miyazaki, Masaki
Taniguchi, Toru
Yamaguchi, Akitake
Uoto, Kouichi
Wakabayashi, Takanori
Sugimoto, Yuuichi
Setoguchi, Masaki
Author_xml – fullname: Wakabayashi, Takanori
– fullname: Miyazaki, Masaki
– fullname: Taniguchi, Toru
– fullname: Yoshida, Shoko
– fullname: Yoshida, Keisuke
– fullname: Uoto, Kouichi
– fullname: Setoguchi, Masaki
– fullname: Yamaguchi, Akitake
– fullname: Sugimoto, Yuuichi
BookMark eNrjYmDJy89L5WSQc_EMDvAM8g-IDAry9_F08fRzVXBxDfIMcwzxDHMN5mFgTUvMKU7lhdLcDMpuriHOHrqpBfnxqcUFicmpeakl8aHBRgZGJkYmZpYWlo6GxsSpAgBRYiSk
ContentType Patent
DBID EVB
DatabaseName esp@cenet
DatabaseTitleList
Database_xml – sequence: 1
  dbid: EVB
  name: esp@cenet
  url: http://worldwide.espacenet.com/singleLineSearch?locale=en_EP
  sourceTypes: Open Access Repository
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Sciences
ExternalDocumentID US2024246989A1
GroupedDBID EVB
ID FETCH-epo_espacenet_US2024246989A13
IEDL.DBID EVB
IngestDate Fri Aug 16 05:56:11 EDT 2024
IsOpenAccess true
IsPeerReviewed false
IsScholarly false
Language English
LinkModel DirectLink
MergedId FETCHMERGED-epo_espacenet_US2024246989A13
Notes Application Number: US202318450009
OpenAccessLink https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240725&DB=EPODOC&CC=US&NR=2024246989A1
ParticipantIDs epo_espacenet_US2024246989A1
PublicationCentury 2000
PublicationDate 20240725
PublicationDateYYYYMMDD 2024-07-25
PublicationDate_xml – month: 07
  year: 2024
  text: 20240725
  day: 25
PublicationDecade 2020
PublicationYear 2024
RelatedCompanies Daiichi Sankyo Company, Limited
RelatedCompanies_xml – name: Daiichi Sankyo Company, Limited
Score 3.5594203
Snippet A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present...
SourceID epo
SourceType Open Access Repository
SubjectTerms CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
Title DISPIROPYRROLIDINE DERIVATIVES
URI https://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240725&DB=EPODOC&locale=&CC=US&NR=2024246989A1
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwY2BQsTQyTQPWC5a6KUmJKbomFqCBphRgnycZWJ2ZGgGJFPAMvq-fmUeoiVeEaQQTQw5sLwz4nNBy8OGIwByVDMzvJeDyugAxiOUCXltZrJ-UCRTKt3cLsXVRg_aOwcd9maq5ONm6Bvi7-DurOTvbhgar-QWB5YzAtyU6AvtKrMCGtDloAZhrmBNoX0oBcqXiJsjAFgA0L69EiIEpNU-YgdMZdveaMAOHL3TKG8iE5r5iEQY50FIPzyD_gMigIH8fTxdPP1cFF2BHLMwxxDPMNViUQdnNNcTZQxdoUTzcX_GhwciuMhZjYAH2-FMlGBQMUtJMk43SLNMsgJ0v06RES4NEQwuLlBTDZCPTJJMUQ0kGGXwmSeGXlmbgAnFBA5RGpjIMLCVFpamywJq1JEkOHCAAKLh4Lg
link.rule.ids 230,309,783,888,25578,76886
linkProvider European Patent Office
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1ZS8NAEB5KFeubVsWj1oKSt2CTZiV5CNLmINFc5KI-hSSbgCC12Ih_38mSap_6siw7MHvA7Ow3OwfAgyKSGvWCwtMip7wkt4YmipinRHVGRGwo-8F3vScrkV6WZNmDj20sDMsT-sOSI6JElSjvDbuv1_9GLJ35Vm4ei3cc-nw2Y1XnOnTM0n0RTl-oRuDrvsZpmppEnBcymsiqJc4RKx3gI1tu5cFIF21cynpXqZgncBggv1VzCr1qNYSBtq29NoQjt_vyxm4nfZszGLeuHnboB29h6Du2bnvGREcgls5jOzWic7g3jVizeJwo-9tXlkS7q5pdQB8Rf3UJkymtSSnWSi0j-CJFrkxzQZYpFUqRFBIVrmC0j9P1fvIdDKzYdTLH9l5v4LgltcZKkYyg33x9V7eoZZtizA7nF_TneyA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Apatent&rft.title=DISPIROPYRROLIDINE+DERIVATIVES&rft.inventor=Wakabayashi%2C+Takanori&rft.inventor=Miyazaki%2C+Masaki&rft.inventor=Taniguchi%2C+Toru&rft.inventor=Yoshida%2C+Shoko&rft.inventor=Yoshida%2C+Keisuke&rft.inventor=Uoto%2C+Kouichi&rft.inventor=Setoguchi%2C+Masaki&rft.inventor=Yamaguchi%2C+Akitake&rft.inventor=Sugimoto%2C+Yuuichi&rft.date=2024-07-25&rft.externalDBID=A1&rft.externalDocID=US2024246989A1