DISPIROPYRROLIDINE DERIVATIVES

A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interacti...

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Main Authors Wakabayashi, Takanori, Miyazaki, Masaki, Taniguchi, Toru, Yoshida, Shoko, Yoshida, Keisuke, Uoto, Kouichi, Setoguchi, Masaki, Yamaguchi, Akitake, Sugimoto, Yuuichi
Format Patent
LanguageEnglish
Published 25.07.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Summary:A compound that inhibits interaction between murine double minute 2 (Mdm2) protein and p53 protein and exhibits anti-tumor activity is provided. The present invention provides a dispiropyrrolidine derivative represented by the following formula (1), which has various substituents, inhibits interaction between Mdm2 protein and p53 protein and exhibits anti-tumor activity, wherein R1, R2, R3, ring A, and ring B in formula (1) respectively have the same meanings as defined in the specification.
Bibliography:Application Number: US202318450009