IL4I1 INHIBITORS AND METHODS OF USE

The invention discloses a synthesizing method of benzimidazole derivant and intermediate, which is characterized by the following: proceeding arylation among aryl halide and primary amine; adopting L-pro as additive, cuprous iodide as catalyst; proceeding molecular arylation coupling reaction for ar...

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Main Authors YAN, Xin, TUDOR, Matthew, HAIDLE, Andrew M, LESBURG, Charles A, ZHENG, Xiao Mei, ZHAO, Lianyun, LUX, Michaelyn Claire, JEWELL, James P, LARSEN, Matthew A, GIAMBASU, George Madalin, SILIPHAIVANH, Phieng, SANYAL, Sulagna, JOHNSON, Rebecca, WHITE, Catherine M, KAPLAN, William P, PU, Qinglin, HOPKINS, Brett A, LI, Derun, LIU, Ping
Format Patent
LanguageEnglish
Published 25.07.2024
Subjects
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Summary:The invention discloses a synthesizing method of benzimidazole derivant and intermediate, which is characterized by the following: proceeding arylation among aryl halide and primary amine; adopting L-pro as additive, cuprous iodide as catalyst; proceeding molecular arylation coupling reaction for aryl iodide or aryl bromide and primary amine; adopting iodo phenylamine compound and bromophenylamine compound as starting material; synthesizing the material through several-step transformation.
Bibliography:Application Number: US202218556196