USING ELECTROPHORESIS FOR DISEASE DETECTION BASED ON CONTROLLED MOLECULAR CHARGE

Electrophoresis is used to identify presence of a target compound in a patient sample based on a charge state of the compound. The charge state of the compound correlates to a total net charge of a binder conjugated to the compound. The bound complex is then applied to the electrophoresis substrate....

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Bibliographic Details
Main Authors GURKAN, Umut Atakan, BELL, David Richard, GALEN, Peter, ERICKSON, Ariane Elizabeth, LIND, Matthew Christian, WITTE, Tyler
Format Patent
LanguageEnglish
Published 18.07.2024
Subjects
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
PHYSICS
TESTING
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Summary:Electrophoresis is used to identify presence of a target compound in a patient sample based on a charge state of the compound. The charge state of the compound correlates to a total net charge of a binder conjugated to the compound. The bound complex is then applied to the electrophoresis substrate. An electric potential is applied to the substrate for a time period and causes the bound complex to migrate toward the electrode with opposite charge of the bound complex at a migration velocity to form a migration pattern over the time period. At some time during or at the end of the time period, the bound complex produces a bound complex band as a result of its migration across the substrate. The presence of the compound is identified based on the bound complex band and one or both of the migration pattern and the migration velocity.
Bibliography:Application Number: US202418618784