5-(5-(PIPERIDIN-4-YL)THIENO[3,2-C]PYRAZOL-2-YL]INDAZOLE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS FOR SPLICING NUCLEIC ACIDS AND FOR THE T
The present disclosure features compounds e.g. of formula (I-a) and similar compounds e.g. of formulae (1-g), (1-i), (1-j), (III), (III-a), (III-b) and (IV) disclosed herein and other related compounds, and pharmaceutical compositions thereof. The present disclosure further discloses said compounds...
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Main Authors | , , , , , , , |
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Format | Patent |
Language | English |
Published |
18.07.2024
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Subjects | |
Online Access | Get full text |
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Summary: | The present disclosure features compounds e.g. of formula (I-a) and similar compounds e.g. of formulae (1-g), (1-i), (1-j), (III), (III-a), (III-b) and (IV) disclosed herein and other related compounds, and pharmaceutical compositions thereof. The present disclosure further discloses said compounds and their compositions for use in methods of modulating nucleic acid splicing, as well as said compounds for use in methods of treating e.g.: ·proliferative diseases, such as e.g. cancer, benign neoplasms or angiogenesis, ·neurological diseases or disorders, such as e.g. Huntington's disease, ·autoimmune diseases or disorders, immunodeficiency diseases or disorders, lysosomal storage disease or disorder, cardiovascular diseases or disorders, metabolic diseases or disorders, respiratory diseases or disorders, renal diseases or disorders, or infectious diseases. Exemplary compounds are e.g. 5-[5-(piperidin-4-yl)thieno[3,2-c]pyrazol-2-yl]indazole and 5-[2-(piperidin-4-yl)-[1,2,4]triazolo[3,2-b] [1,3]thiazol-5-yl]indazole derivatives and related compounds. |
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Bibliography: | Application Number: US202118014057 |