METHODS AND COMPOSITIONS FOR TREATING DISORDERS WITH ORAL SYSTEMICALLY BIOAVAILABLE BUTYRATE CONJUGATES

Described herein are novel methods of treating disorders using oral, systemically bioavailable forms of butyrate. Aspects of the disclosure relate to a method for treating a disorder in a subject comprising administering the oral, systemically bioavailable composition to the subject, wherein the dis...

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Bibliographic Details
Main Authors CAO, Shijie, BUDINA, Erica, WATKINS, Elyse, RACZY, Michal, HUBBELL, Jeffrey
Format Patent
LanguageEnglish
Published 27.06.2024
Subjects
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Summary:Described herein are novel methods of treating disorders using oral, systemically bioavailable forms of butyrate. Aspects of the disclosure relate to a method for treating a disorder in a subject comprising administering the oral, systemically bioavailable composition to the subject, wherein the disorder is selected from inflammatory bowel disease (IBD), multiple sclerosis (MS), a neuroinflammatory condition, food allergies, rheumatoid arthritis (RA), asthma, celiac disease, non-alcoholic steatohepatitis (NASH), diabetes, Alzheimer's disease (AD), inflammaging, beta-hemoglobinopathies, vascular inflammatory conditions, atopic dermatitis and psoriasis, pulmonary fibrosis, and systemic sclerosis.
Bibliography:Application Number: US202218556006