METHODS AND SYSTEMS FOR CHARACTERIZING PHOSPHOSERINE-CONTAINING POLYPEPTIDES

According to some aspects, systems and methods for characterizing phosphoserine-containing polypeptides are described. In some embodiments, a phosphoserine residue of a polypeptide may be converted to a dehydroalanine residue. Some aspects are directed to a method of reacting a polypeptide comprisin...

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Bibliographic Details
Main Authors Huang, Haidong, Kamber, David N, Skinner, Kenneth
Format Patent
LanguageEnglish
Published 06.06.2024
Subjects
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS OR TEST PAPERS THEREFOR
CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES
ENZYMOLOGY
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
PROCESSES OF PREPARING SUCH COMPOSITIONS
SPIRITS
VINEGAR
WINE
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Summary:According to some aspects, systems and methods for characterizing phosphoserine-containing polypeptides are described. In some embodiments, a phosphoserine residue of a polypeptide may be converted to a dehydroalanine residue. Some aspects are directed to a method of reacting a polypeptide comprising at least one dehydroalanine residue with a protected thiol compound comprising a click chemistry handle (e.g., an azide, an alkyne) to provide a functionalized polypeptide comprising a click chemistry handle. Some aspects are directed to systems and methods of characterizing phosphoserine residues in polypeptides (e.g., identifying and/or determining the location of a phosphoserine residue) and/or methods of preparing samples for such systems and methods.
Bibliography:Application Number: US202318491699