CYCLIC COMPOUND HAVING SELECTIVE INHIBITORY ACTION ON KRAS OVER HRAS AND NRAS

Cyclic compounds and oligopeptide compounds that selectively inhibit KRAS were found. Oligopeptide compounds and non-natural amino acids useful for producing a cyclic compound were also found. Moreover, cyclic compounds and oligopeptide compounds were found to interact with an amino acid residue spe...

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Main Authors WAKAMIYA, Yuma, HAYASHI, Ryuji, HASHIMOTO, Satoshi, TAMIYA, Minoru, KAWADA, Hatsuo, TAKANO, Koji, KAGE, Mirai, KOTAKE, Tomoya, MORITA, Yuya
Format Patent
LanguageEnglish
Published 16.05.2024
Subjects
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Summary:Cyclic compounds and oligopeptide compounds that selectively inhibit KRAS were found. Oligopeptide compounds and non-natural amino acids useful for producing a cyclic compound were also found. Moreover, cyclic compounds and oligopeptide compounds were found to interact with an amino acid residue specific to KRAS.
Bibliography:Application Number: US202218289592