TWO-FIELD COUPLING CROSSLINKED, INJECTABLE, MOLDABLE AND PRINTABLE GRANULAR HYDROGEL MATERIAL, PREPARATION METHOD THEREOF AND APPLICATION THEREOF

• Main Authors: CHEN, Kaiwen, WANG, Huanan
• Format: Patent
• Language: English
• Published: 28.03.2024
• Subjects: CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; HUMAN NECESSITIES; HYGIENE; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES; MEDICAL OR VETERINARY SCIENCE; METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL

An injectable, moldable and printable gramular hydrogel material crosslinked by non-covalent and covalent bonds, a preparation method therefor, and applications thereof are provided. The material uses gelatin particles or particles that have core-shell structures as basic structural units, and forms a continuous and porous particle network by means of the reversible non-covalent crosslinking and covalent bond crosslinking of the particles. The gelatin particles or the particles that have core-shell structures form a continuous porous particle network by means of reversible self-assembly under the effect of the non-covalent bonds, thus achieving injectable, printable, moldable and self-healing properties. Furthermore, high strength granular hydrogels are formed by means of initiating covalent crosslinking. The material can be used as a drug-sustained release carrier, a tissue engineering scaffold and a tissue adhesive hemostatic material in the field of biomedicine.